The topography of chromosome replication in yeast: a genomic view

Salk Institute Conference on Eukaryotic DNA Replication
La Jolla, CA
September 2000

David Collingwood¹, M. Raghuraman², E. Winzeler³, S. Hunt², L. Wodicka⁴, A. Conway⁵, D. Lockhart⁴, R. Davis⁶, B. Brewer², W. Fangman²

1. University of Washington, Mathematics
2. University of Washington, Genetics
3. Genomics Institute of Novartis Research Foundation
4. Affymetrix
5. Silicon Genetics
6. Stanford University

Problem: Determine the replication timing in the yeast Saccharomyces cerevisiae. In particular, identify the replication initiation sites.

Old approach

New approach

Data output

Chromosome 6 (part1)

Chromosome 6 (part2)

Chromosome 10

Genomewide results